p53: an overview of over two decades of study.
p53 is the most commonly mutated gene in human cancers. It encodes a 53 kilodalton protein with several evolutionarily conserved domains viz sequence-specific DNA binding, tetramerisation, SH3 molecule binding, C-terminal and N-terminal. Existing in the cell at a very low level and in a relatively i...
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| Main Authors: | , |
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| Format: | Article |
| Published: |
2001
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| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pubmed/16329542 http://www.ncbi.nlm.nih.gov/pubmed/16329542 |
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