In vitro anti-acetyl cholinesterase and antioxidant activity of selected Malaysian plants
The aim of this study is to discover and identify the potential plant extracts that could be vital against Alzheimer’s disease (AD). It is a neurodegenerative disease affecting the brain. The most promising target for the symptomatic treatment and slowing of AD progression is cholinesterase inhibito...
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| Format: | Artikel |
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Inovare Academic Science
2014
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| Capaian Atas Talian: | https://innovareacademics.in/journals/index.php/ajpcr/article/view/1169 https://innovareacademics.in/journals/index.php/ajpcr/article/view/1169 |
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| Ringkasan: | The aim of this study is to discover and identify the potential plant extracts that could be vital against Alzheimer’s disease (AD). It is a
neurodegenerative disease affecting the brain. The most promising target for the symptomatic treatment and slowing of AD progression is
cholinesterase inhibitors from plants.
To evaluate the antioxidant and anti-acetylcholinesterase (AChEI) activities of leaves and roots macerated and refluxed with ethanol
extracts, from four medicinal plants, namely; C.asiatica, M.pudica, C.pumila,and L.camara. DPPH and β-carotene assays were used to
determine antioxidant activity; whereas Ellman’s colorimetric method was adopted to quantify AChEI activity.
Among all tested samples, the refluxed ethanol extract ofM.pudicaleaves exhibited the highest AChEI activity (IC50 = 0.0114 mg/ml)
whereas, M. pudica roots showed high antioxidant activity (DPPH; IC50 = 0.0102 mg/ml).
Results reveal that all plant extracts studied possess anti-oxidant properties. Most potent extracts could be a lead to novel antioxidants
and acetyl cholinesterase inhibitors, for the treatment of AD. |
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