Computer-aided process design tools for debottlenecking a batch pharmaceutical production
The main objective of this work is to model and to debottleneck a batch pharmaceutical production with computer-aided process design (CAPD) and simulation tools. An eye drop production case study is firstly modelled based on a pharmaceutical production plant. Throughput analysis is next...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2008
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| Subjects: | |
| Online Access: | http://eprints.utm.my/18872/ http://eprints.utm.my/18872/ http://eprints.utm.my/18872/1/Tan%20Jully2007_COMPUTER%20AIDED%20PROCEss%20DEsIGN%20TOOLs.pdf |
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| Summary: | The main objective of this work is to model and to debottleneck a batch pharmaceutical production with computer-aided process
design (CAPD) and simulation tools. An eye drop production case study is firstly modelled based on a pharmaceutical production
plant. Throughput analysis is next utilised to identify process bottlenecks that limit the increase of production and to evaluate
different debottlenecking schemes. Scheme 1 considers an effort to maximise process throughput for a single batch operation, while
Schemes 2 and 3 explore the possibility of minimising combined utilisation value of the process bottleneck. With the increase of
batch throughput, installation of a new labelling process and the addition of an intermediate tank, Scheme 3 is identified as the
debottlenecking scheme that achieves the increased production demand of 25%. |
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