Synthesis of 2'-hydroxy-4'-O-prenylchalcones
A facile method has been applied to synthesis 4' -O-prenychalcones through Claisen-Schmidt condensation between prenylated acetophenone and benzaldehyde derivatives giving chalcone s 1-5. The structures of the compounds were verified through spectroscopic methods; NMR and IR spectroscopies. The...
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| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://eprints.utm.my/62285/ http://eprints.utm.my/62285/1/FarediahAhmad2015_Synthesisof2%27-Hydroxy-4%27-O-Prenylchalcones.pdf |
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| Summary: | A facile method has been applied to synthesis 4' -O-prenychalcones through Claisen-Schmidt condensation between prenylated acetophenone and benzaldehyde derivatives giving chalcone s 1-5. The structures of the compounds were verified through spectroscopic methods; NMR and IR spectroscopies. These compounds are; 2'-hydroxy-4-(N,Ndimethyl) amino-4'-0-prenylc halcone (1), 2'-hydroxy-2-methox y-4' -O-prenylchalcone (2), 2'hydroxy- 4-isopropyl-4' -O-prenylchalcone (3), 2'-hydroxy-3,4-dimethoxy-4'-0prenylchalcone (4) and 2'-hydroxy-4-nitro-4'-0-prenylchalcone (5). The compounds were later subjec ted to antibacteria l activities using micro-dilution method against Gram-positive and Gram-nega tive bacteria. |
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