Regenerated cellulose/beta-cyclodextrin scaffold prepared using ionic liquid
Regenerated cellulose/β-cyclodextrin (RC/β-CD) tissue engineering scaffolds were fabricated by two particulate leaching techniques using environmental-friendly 1-butyl-3-methylimidazolium chloride (BMIMCl) ionic liquid. In one case, the pore inducing particles were water-soluble (edible salt) and in...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Elsevier Ltd.
2014
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| Subjects: | |
| Online Access: | http://eprints.utm.my/62425/ http://eprints.utm.my/62425/ http://eprints.utm.my/62425/ |
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| Summary: | Regenerated cellulose/β-cyclodextrin (RC/β-CD) tissue engineering scaffolds were fabricated by two particulate leaching techniques using environmental-friendly 1-butyl-3-methylimidazolium chloride (BMIMCl) ionic liquid. In one case, the pore inducing particles were water-soluble (edible salt) and in the other, they were water-insoluble poly (methyl methacrylate) (PMMA). The water-soluble particulate leaching and water-insoluble methods resulted in scaffolds with 70-75% and 91-93% porosity, respectively. X-ray diffraction revealed lower crystallinity of the RC/β-CD scaffolds as compared to pure RC. The RC/β-CD scaffolds prepared by water-insoluble leaching method showed the highest water uptake properties. In vitro cytotoxicity test demonstrated that RC/β-CD scaffolds are cytocompatible. |
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